Photophysical modulations of biologically potent small molecules in biocompatible microheterogeneous environments created by cyclodextrins and lipid vesicles

254-264Small molecules having biological potency are applied in all the avenues of chemical, pharmaceutical, and biological research. Typically, the small molecules are delivered to the biological environment using a compatible host that acts as a carrier for the compound. The internal environments of the hosts are typically non-polar or less polar than the bulk aqueous environment so that the potent drugs, most of them being hydrophobic, can get encapsulated to be carried to the target. On incorporation, the photophysics of the compounds may change as compared to the external atmosphere. This may alter their inherent properties and mode of functioning. In this perspective article, the relevant progress in host-guest chemistry in biologically potent environment aided by cyclodextrins and lipid vesicles has been discussed