Synthesis and biological evaluation of novel thiazole and thiadiazole based secondary amines as antibacterial agents

1212-1219The synthesis of a series of N-(4-substitutedbenzyl)-2-amino-4-aryl-1,3-thiazoles/N-(4-substitutedbenzyl)-2-amino-5-aryl-1,3,4-thiadiazoles has been reported by the reduction of N-(4-substituted benzylidene)-2-amino-4-aryl-1,3-thiazoles/N-(4-substitutedbenzylidene)-2-amino-5-aryl-1,3,4-thiadiazoles with NaBH4, which in turn has been synthesized by the reaction of 2-amino-4-aryl-1,3-thiazoles/2-amino-4-substituted-1,3,4-thiadiazoles with substituted benzaldehydes in the presence of catalytic amount of H2SO4 in good to excellent yields. Synthesized compounds have been evaluated for in vitro antibacterial activity against both Gram-Positive and Gram-Negative bacteria. Some of them exhibit moderate activity in comparison with the standard Ciprofloxacin, such as compound 9a which has shown good antibacterial activity with MIC value of 125 µg/mL against S. aureus and compound 9l which has shown good antibacterial activity with MIC value of 150 µg/mL against E. coli