Quantitative aspects of intramolecular interactions in ternary complexes of purine nucleotides and amino acids

769-774Interaction Of bivalent metal ions (CO2+,Ni2+, Cu2+,Zn2+) with purine nucleotides (5' - guanosinemono-phosphate and 5' - inosinemonophonsphate) and amino acids (alanine, phenylalanine and tryptophan) in I: I and I: I: 1 ratios has been investigated by potentiometric pH measurements and formation constants in various systems are determined by computer program. The extra stabilization is expressed in terms of ∆logK. The hydrophobic interactions associated with different amino acids and nucleotides have been identified with parameters like ∆logK, Kl % of (MLA)st' and ∆Go The pH profiles of various species are generated in order to identify the stable species