Add to ORKG2313-23203,5-Bis(arylmethylene)-4-piperidone derivatives have emerged as novel clusters of cytotoxic agents. The focus of the current research has been to tine tune the biological activity of these compounds by rational alteration of <span style="mso-bidi-font-family:Arial; mso-bidi-language:HI">substituents on this pharmacophore to <span style="mso-bidi-font-family: Arial;mso-bidi-language:HI">increase potency <span style="mso-bidi-language: HI">and selectivity. These compounds arc presumed to bc devoid of gcnctoxicity and act <span style="mso-bidi-font-family: Arial;mso-bidi-language:HI">by selective thiolation of proteins. Anticancer behavior of nine clusters of 3,5-bis(arylmethylene)-4-piperidone derivatives have been rev...
The principal objective of this study was the examination of the theory of cytotoxic synergism. In t...
A series of 3,5-bis(benzylidene)-4-piperidones 2a–u were prepared as candidate cytotoxic agents. In ...
A series of 1-[3-(2-hydroxyethylsulfanyl)propanoyl]-3,5-bis(benzylidene)-4-piperidones 4a-e display ...
A series of 1-acyl-3,5-bis(benzylidene)-4-piperidones 3-7 were designed and synthesized as novel cyt...
A series of 1-acyl-3,5-bis(benzylidene)-4-piperidones 3-7 were designed and synthesized as novel cyt...
Novel 4-piperidone derivatives <b>2a</b>–<b>f</b> are disclosed as potent cytotoxins. Many of these ...
Novel clusters of 3,5-bis(benzylidene)-4-oxo-1-piperidinyl dimers 3-5 were evaluated against human M...
Novel clusters of 3,5-bis(benzylidene)-4-oxo-1-piperidinyl dimers 3-5 were evaluated against human M...
Novel clusters of 3,5-bis(benzylidene)-4-oxo-1-piperidinyl dimers 3–5were evaluated against human Mo...
Novel 4-piperidone derivatives 2a-f are disclosed as potent cytotoxins. Many of these compounds are ...
Novel 4-piperidone derivatives 2a-f are disclosed as potent cytotoxins. Many of these compounds are ...
Twenty-one NH- and N-methyl-3,5-bis-(arylidenyl)-4-piperidone analogs of curcumin, 12 of which are n...
Twenty-one NH- and N-methyl-3,5-bis-(arylidenyl)-4-piperidone analogs of curcumin, 12 of which are n...
Twenty-one NH- and N-methyl-3,5-bis-(arylidenyl)-4-piperidone analogs of curcumin, 12 of which are n...
Novel 3,5-bis(benzylidene)-1-[3-(2-hydroxyethylthio)propanoyl]piperidin-4-ones (3a-e) display potent...
The principal objective of this study was the examination of the theory of cytotoxic synergism. In t...
A series of 3,5-bis(benzylidene)-4-piperidones 2a–u were prepared as candidate cytotoxic agents. In ...
A series of 1-[3-(2-hydroxyethylsulfanyl)propanoyl]-3,5-bis(benzylidene)-4-piperidones 4a-e display ...
A series of 1-acyl-3,5-bis(benzylidene)-4-piperidones 3-7 were designed and synthesized as novel cyt...
A series of 1-acyl-3,5-bis(benzylidene)-4-piperidones 3-7 were designed and synthesized as novel cyt...
Novel 4-piperidone derivatives <b>2a</b>–<b>f</b> are disclosed as potent cytotoxins. Many of these ...
Novel clusters of 3,5-bis(benzylidene)-4-oxo-1-piperidinyl dimers 3-5 were evaluated against human M...
Novel clusters of 3,5-bis(benzylidene)-4-oxo-1-piperidinyl dimers 3-5 were evaluated against human M...
Novel clusters of 3,5-bis(benzylidene)-4-oxo-1-piperidinyl dimers 3–5were evaluated against human Mo...
Novel 4-piperidone derivatives 2a-f are disclosed as potent cytotoxins. Many of these compounds are ...
Novel 4-piperidone derivatives 2a-f are disclosed as potent cytotoxins. Many of these compounds are ...
Twenty-one NH- and N-methyl-3,5-bis-(arylidenyl)-4-piperidone analogs of curcumin, 12 of which are n...
Twenty-one NH- and N-methyl-3,5-bis-(arylidenyl)-4-piperidone analogs of curcumin, 12 of which are n...
Twenty-one NH- and N-methyl-3,5-bis-(arylidenyl)-4-piperidone analogs of curcumin, 12 of which are n...
Novel 3,5-bis(benzylidene)-1-[3-(2-hydroxyethylthio)propanoyl]piperidin-4-ones (3a-e) display potent...
The principal objective of this study was the examination of the theory of cytotoxic synergism. In t...
A series of 3,5-bis(benzylidene)-4-piperidones 2a–u were prepared as candidate cytotoxic agents. In ...
A series of 1-[3-(2-hydroxyethylsulfanyl)propanoyl]-3,5-bis(benzylidene)-4-piperidones 4a-e display ...