Synthesis of 1,5-benzothiazepines: Part XXXII - Synthesis and antimicrobial studies of 8-substituted-2,5-dihydro-2-(4-pyridyl)-4-(2-thienyl)-1,5-benzothiazepines

1525-1530The reactions of 5-substituted-2-aminobcnzenethiols, the substituents being F, CI, Br, CH3, OCH3 and OC2H5 4a-f, with an α, β-unsaturated heterocyclic ketone, 3-(4-pyridyl)-1-(2-thienyl)-2-propcnone, have been carried out in dry toluene containing piperidine. The products, 8-substituted-2, 5-dihydro-2-(4-pyridyl)-4-(2-thicnyl)-1,5-benzothiazepines, 5a-f, obtained in 65-70% yields, have been characterized by microestimations for C, H, N and JR, 1H NMR and mass spectral studies. The synthesized compounds have been screened for antimicrobial activity against the bacteria Escherichia coli and <span style="mso-bidi-font-family: Arial;mso-bidi-language:HI">GPO and fungi, Aspergillus niger, Aspcrgillus flavus and Curvularia <span style="mso-bidi-font-family: Arial;mso-bidi-language:HI">lunata. <span style="mso-bidi-language: HI">All the compounds show good antibacterial and antifungal activity.