Add to ORKG775-785Specific inactivation of gene expression through ribozymes is a relatively novel approach. Specially designed ribozymes can be used to bind and bring out site specific cleavage of target viral mRNA. Recent reports suggest that ribozymes can be used effectively in cell culture against a variety of RNA targets, including, viral, endogenous and transfected sequences. Besides, destroying mRNA. they can be used to repair mutant RNAs as well, Of many catalytic motifs, hairpin and hammerhead appears to be more promising as therapeutic agents and are being tested in clinical trials
Using an in vitro selection procedure, we have previously isolated RNase P ribozyme variants that ef...
Using an in vitro selection procedure, we have previously isolated RNase P ribozyme variants that ef...
grantor: University of TorontoRibozymes are small, catalytic RNA molecules which possess e...
The discovery that RNA can act as a biological catalyst, as well as a genetic molecule, indicated th...
Ribozymes are a class of RNA molecules that can perform catalytically in the absence of protein. Spe...
Ribozymes have the potential to ablate the expression of any gene in a sequence-specific manner and,...
Ribozymes have the potential to ablate the expression of any gene in a sequence-specific manner and,...
Hammerhead ribozymes are small RNA molecules that can be designed to specifically recognize and clea...
Ribozymes can be used to cleave specific mRNAs so as to prevent their translation. This presents an ...
The limited efficacy of current therapeutic approaches for a number of socially relevant human disea...
Ribozymes can be used to cleave specific mRNAs so as to prevent their translation. This presents An ...
RNA molecules with enzymatic activity (ribozymes) targeted to the genome of HIV-1 were developed and...
RNA molecules with enzymatic activity (ribozymes) targeted to the genome of HIV-1 were developed and...
5siThe limited efficacy of current therapeutic approaches for a number of socially relevant human di...
Ribozymes and deoxyribozymes (collectively referred to as nucleic acid enzymes) can be designed to c...
Using an in vitro selection procedure, we have previously isolated RNase P ribozyme variants that ef...
Using an in vitro selection procedure, we have previously isolated RNase P ribozyme variants that ef...
grantor: University of TorontoRibozymes are small, catalytic RNA molecules which possess e...
The discovery that RNA can act as a biological catalyst, as well as a genetic molecule, indicated th...
Ribozymes are a class of RNA molecules that can perform catalytically in the absence of protein. Spe...
Ribozymes have the potential to ablate the expression of any gene in a sequence-specific manner and,...
Ribozymes have the potential to ablate the expression of any gene in a sequence-specific manner and,...
Hammerhead ribozymes are small RNA molecules that can be designed to specifically recognize and clea...
Ribozymes can be used to cleave specific mRNAs so as to prevent their translation. This presents an ...
The limited efficacy of current therapeutic approaches for a number of socially relevant human disea...
Ribozymes can be used to cleave specific mRNAs so as to prevent their translation. This presents An ...
RNA molecules with enzymatic activity (ribozymes) targeted to the genome of HIV-1 were developed and...
RNA molecules with enzymatic activity (ribozymes) targeted to the genome of HIV-1 were developed and...
5siThe limited efficacy of current therapeutic approaches for a number of socially relevant human di...
Ribozymes and deoxyribozymes (collectively referred to as nucleic acid enzymes) can be designed to c...
Using an in vitro selection procedure, we have previously isolated RNase P ribozyme variants that ef...
Using an in vitro selection procedure, we have previously isolated RNase P ribozyme variants that ef...
grantor: University of TorontoRibozymes are small, catalytic RNA molecules which possess e...