Diastereoselective synthesis of fused lactone-pyrrolidinones; application to a formal synthesis of (-)-salinosporamide A.
- Logan, A
- Sprague, S
- Foster, R
- Marx, L
- Garzya, V
- Hallside, M
- Thompson, A
- Burton, J
Publication date
January 2014
DOI Publisher
American Chemical Society (ACS) ISSN
1523-7060 Citation count (estimate)
9Abstract
A mild, diastereoselective synthesis of fused lactone-pyrrolidinones using an oxidative radical cyclization is reported. The methodology is demonstrated in a formal synthesis of (-)-salinosporamide A
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