225-230The object of the present study is to detect the ·p53 tumour suppressor gene and proliferation cell nuclear antigen (PCNA) expression in breast carcinoma by immunohistochemistry and correlate them with the prognostic parameters. Total 35 cases of primary breast carcinoma were studied and classified histologically. Paraffin sections were stained by using monoclonal antibody D07 for p53 protein and PC-10 for PCNA. Out of 35 cases, 16 (45.7%) were p53 positive and 25 (71.4%) were PCNA positive. The mean PCNA labelling index (PCNA LI ± SD) was 58.97 ± 22.72 in tumors positive for both p53+ and PCNA+ while cases negative for p53- and positive for PCNA+ has higher PCNA LI ± SD (59.24 ± 18.97). The difference in the two groups was ...
The study was designed to detect differences in the nuclear morphology of tumours and tumour cell po...
P53; a tumor suppressor gene has known to have a role in a group of human cancers. Its role in breas...
Abstract- Involvement of genetic alterations in breast cancer, one of the most common types of femal...
Background and Objectives Breast cancer continues to frustrate oncologists worldwide. In India, it i...
Sixty-six unselected breast cancers were analyzed in cytologic smears and histologic sections for th...
Proliferating cell nuclear antigen (PCNA) appears in the cell nuclei during the late G1 to S phases ...
Breast cancer is an increasingly important cause of illness and death among women. In recent years s...
The p53 gene is located on the short arm of chromosome 17. It encodes a 53-kd nuclear protein (p53) ...
Objective: To characterize p53 and PCNA expression in primary tumors and lymph nodes metastases of o...
Objective: To assess the independent and interdependent prognostic value of proliferating cell nucl...
The expression of the p53 gene product was investigated immunocytochemically in a retrospective seri...
The nuclear phosphoprotein p53 is expressed in all normal cells and appears to function in cell cycl...
The study was designed to detect differences in the nuclear morphology of tumours and tumour cell po...
P53; a tumor suppressor gene has known to have a role in a group of human cancers. Its role in breas...
Abstract- Involvement of genetic alterations in breast cancer, one of the most common types of femal...
Background and Objectives Breast cancer continues to frustrate oncologists worldwide. In India, it i...
Sixty-six unselected breast cancers were analyzed in cytologic smears and histologic sections for th...
Proliferating cell nuclear antigen (PCNA) appears in the cell nuclei during the late G1 to S phases ...
Breast cancer is an increasingly important cause of illness and death among women. In recent years s...
The p53 gene is located on the short arm of chromosome 17. It encodes a 53-kd nuclear protein (p53) ...
Objective: To characterize p53 and PCNA expression in primary tumors and lymph nodes metastases of o...
Objective: To assess the independent and interdependent prognostic value of proliferating cell nucl...
The expression of the p53 gene product was investigated immunocytochemically in a retrospective seri...
The nuclear phosphoprotein p53 is expressed in all normal cells and appears to function in cell cycl...
The study was designed to detect differences in the nuclear morphology of tumours and tumour cell po...
P53; a tumor suppressor gene has known to have a role in a group of human cancers. Its role in breas...
Abstract- Involvement of genetic alterations in breast cancer, one of the most common types of femal...