Beneficial effects of <i>Zingiber officinale </i>Roscoe on fructose induced hyperlipidemia and hyperinsulinemia in rats

1161-1164Fructose supplementation produced cardinal features of Syndrome-X including significant elevations in serum cholesterol, triglyceride, glucose and insulin and also in body weight. While treatment with methanolic extract of dried rhizomes of Zingiber officinale produced a significant reduction in fructose induced elevation in lipid levels, body weight, hyperglycemia and hyperinsulinemia, treatment with ethyl acetate extract of Z. officinale did not produce any significant change in either of the last two parameters. However, it produced a significant reduction in elevated lipid levels and body weight. The concentration of 6-gingerol was found to be higher in methanolic extract and less in ethyl acetate extract. The results suggest that the methanolic extract of Z. officinale produces better effects as compared to ethyl acetate extract in fructose induced hyperlipidemia associated with insulin resistance. The extent of activity appears to be dependent on the concentration of 6-gingerol present in the extracts