Synthesis and antimicrobial activity of some novel 2,6,7-trisubstituted-2<i>H</i>-3,4- dihydro-1 ,4-benzoxazin-3-one derivatives

905-909The synthesis of a new series of 2H-3,4-dihydro-1,4-benzoxazin-3-one derivatives 1-8 is accomplished in order to determine their antimicrobial activities and study their structure-ac tivity relationships (SAR). The synthesized compounds have been tested in vitro against two Gram-positive, three Gram-negative bacteria and the fungus Candida albicans. The in vitro activity results show that the synthesized compounds exibit MIC values between 50- 12.5 μg/mL for the antimicrobial activity against the tested microorganisms. The antibacterial and antifungal activities or the compounds 1-8 are also compared to several standard drugs