Synthesis of isoxazolyl pyrimidine diones & isoxazolyl thiazolidinones

353-357A series of 3-phenyl/methyl-1-(3-methyl-5-styryl/substituted styryl-4-isoxazolyl) -2,3-dihydro-2-thioxo-4,6(1H, 5H) pyrimidinediones 3 have been prepared from 1-phenyl/methyl-4-(3-methyl-5-styryl/substituted styryl-4-isoxazolyl)thioureas 2 by heating with malonic acid in acetyl chloride. Compounds 2 are obtained by interaction of 4-amino-3-methyl- 5-styryl/ substituted styryl isoxazole 1 with phenyl and methyl isothiocyanates. The thioureas 2 when refluxed with chloroacetic acid and sodium acetate in absolute alcohol afford the corresponding 3-(3-methyl-5-styryl/substituted styryl-4-isoxazolyl)-2-phenyl/methyl imino-4-thiazolidinones 4. All the compounds have been evaluated for their biological activity