Add to ORKG2249-2253Quantitative structure activity relationship (QSAR) analysis is performed on 2,2-dimethyl-4,5-diarylfuran-3(2H)-ones as selective cyclooxygenase-2 (COX-2) inhibitors.Various substituent effects on the activity are analyzed by adopting classical Hansch approach along with the aid of reasonable structural indicator variables. Our investigations suggest that the ortho substitution on the aromatic ring of the parent structure is unfavourable for the activity of mono substituted compounds. While assessing the importance of three dimensional (3D) descriptors, the 3D spatial descriptor connolly solvent excluded volume (CSEV) has been found to play a crucial role in describing the biological activity. The probable hydrophobic ...
We report herein an attempt to generate QSAR models for a large number of structurally diverse compo...
169-175Considering importance of developing selective COX-2 inhibitors, COX-2 binding affinity data ...
2763-2769Cyclooxygenase-2 inhibitors arc of current interest, because these alleviate inflammation,...
Classical Hansch type quantitative structure-activity relationship (QSAR) has been performed on a se...
were performed on a series of 5-aryl-2,2-dialkyl-4-phenyl--3(2H)-furanone derivatives, as selective ...
Abstract: The Gaussian-based 3D-QSAR studies for 58 selective COX-2 (cyclooxygenase-2) inhibitors be...
Selective cyclooxygenase inhibitors have attracted much attention in recent times in the design of n...
AbstractWe have performed the quantitative structure activity relationship (QSAR) study for N-1 and ...
We have performed the quantitative structure activity relationship (QSAR) study for N-1 and C-3 subs...
475-482Quantitative structure activity relationship approach using stepwise regression analysis has ...
QSAR Laboratory, Department of Chemistry, University of Allahabad, Allahabad-211 002, Uttar Pradesh,...
AbstractA series of thirty-two furanone derivatives with their cyclooxygenase-2 inhibitory activity ...
The overexpression of cyclooxygenase-2 (COX-2) was clearly associated with carcinogenesis, and COX-2...
Department of Chemistry, University of Allahabad, Allahabad-211 002, Uttar Pradesh, India E-mail : q...
1692-1698Based on the reported COX-2 selectivity of α,β-diarylheterocycles based NSAIDs' - a new c...
We report herein an attempt to generate QSAR models for a large number of structurally diverse compo...
169-175Considering importance of developing selective COX-2 inhibitors, COX-2 binding affinity data ...
2763-2769Cyclooxygenase-2 inhibitors arc of current interest, because these alleviate inflammation,...
Classical Hansch type quantitative structure-activity relationship (QSAR) has been performed on a se...
were performed on a series of 5-aryl-2,2-dialkyl-4-phenyl--3(2H)-furanone derivatives, as selective ...
Abstract: The Gaussian-based 3D-QSAR studies for 58 selective COX-2 (cyclooxygenase-2) inhibitors be...
Selective cyclooxygenase inhibitors have attracted much attention in recent times in the design of n...
AbstractWe have performed the quantitative structure activity relationship (QSAR) study for N-1 and ...
We have performed the quantitative structure activity relationship (QSAR) study for N-1 and C-3 subs...
475-482Quantitative structure activity relationship approach using stepwise regression analysis has ...
QSAR Laboratory, Department of Chemistry, University of Allahabad, Allahabad-211 002, Uttar Pradesh,...
AbstractA series of thirty-two furanone derivatives with their cyclooxygenase-2 inhibitory activity ...
The overexpression of cyclooxygenase-2 (COX-2) was clearly associated with carcinogenesis, and COX-2...
Department of Chemistry, University of Allahabad, Allahabad-211 002, Uttar Pradesh, India E-mail : q...
1692-1698Based on the reported COX-2 selectivity of α,β-diarylheterocycles based NSAIDs' - a new c...
We report herein an attempt to generate QSAR models for a large number of structurally diverse compo...
169-175Considering importance of developing selective COX-2 inhibitors, COX-2 binding affinity data ...
2763-2769Cyclooxygenase-2 inhibitors arc of current interest, because these alleviate inflammation,...