Synthesis and bioactivity of isoxazolyl thiazoles, isoxazolyl thiazolyl chromen-2-ones, isoxazolyl thiazinanes and isoxazolyl thiazolidinones

643-648A series of substituted methyl/phenyl-[4-methyl/carboethoxy/3-(3-methyl-5-styryl-isoxazol-4-yl)-3H-thiazol-2-ylidene]amines 3, substituted-3-[2-methyl/ phenylimino-3-(3-methyl-5-styryl-isoxazol-4-yl)-2,3-dihydrothiazol-4-yl]chromen-2-ones 4, substituted 5-methyl-2-methyl/phenylimino-3-(3-methyl-5-styryl-isoxazol-4-yl)thiazolidin-4-ones 5 and substituted methyl/phenyl-[3-(3-methyl-5-styryl-isoxazol-4-yl)-[1,3]-thiazinan-2-ylidenejamines 6 have been synthesized by the reaction of substituted 1-methyl/phenyl-3-(3-methyl-5-styryl-isoxazol-4-yl)thioureas 2 with chloroacetone or ethyl bromopyruvate, 3-(ω-bromoacetyl) coumarin, ethyl 2-bromopropionate and 1,3-dibromo- propane, respectively. All the compounds have been evaluated for their antimicrobial activity