Microwave assisted synthesis of some new isoxazolyltriazinan-2-onesz

1784-1786Trimolecular condensation of N-(5-methyl-3- isoxazolyl)- N'-aryl ureas 2 with aqueous formaldehyde and primary amines under microwave irradiation in ethanol leads to 5-alkyl-1-(5-methylisoxazol-3-yl)-3-aryl-[1,3,5] triazinan-2-ones 3 in excellent yields. The intermediates, N-(5-methyl-3- isoxazolyl)-N'-aryl thioureas 2, have been obtained by reaction of 3-amino-5-methylisoxazole 1 with arylisocyanates in toluene under microwave irradiation