Synthesis, crystal structure, DNA binding and cleavage activities of oximato bridged cationic dinuclear copper(II) complex having labile ligands

327-333Oximato bridged dinuclear copper(II) complex [Cu(L)(CH3OH)]2(ClO4)2 with an oxime-Schiff base ligand, viz. 3-[2-[(dimethylamino)ethyl]imino]-2-butanoneoxime (HL), has been synthesized and structurally characterized. The dinuclear copper(II) complex crystallizes in monoclinic space group P21/n with the unit cell parameters, a = 13.3564(9) Å, b = 12.0821(8) Å, c = 17.5045(11) Å, β = 90.097, V = 2824.8(3) Å3, Z = 4, <i style="mso-bidi-font-style: normal">R = 0.0769. The complex shows quasi-reversible cyclic voltammetric response at 0.844V (∆<i style="mso-bidi-font-style: normal">Ep = 276 mV) at 100 mVs-1. The binding studies of the complex with calf thymus DNA has been investigated using absorption spectrophotometry. Cleavage activity of the complex has been carried out on double stranded pBR 322 plasmid DNA by using gel electrophoresis experiments in the absence and in the presence of the oxidant, viz., H2O2.