Evaluation of radioprotective effect of unripe stone fruit pulp extract on liver

125-128To find out natural plant based radioprotectors, a well known medicinal plant, which is acceptable to the body, Aegle marmelos extract (AME), was tested in animals against gamma radiations. Radioprotective effect of unripe stone fruit pulp extract on some liver enzymes of Swiss albino mouse were investigated. For experimental study healthy Swiss albino mice were selected from an inbred colony and divided into two groups and exposed to 8Gy gamma radiation (control) or 8Gy gamma radiation with 100mg/kg body weight of Aegle marmelos extract (experimental), sham irradiated (normal) and plant extract only. Mice were sacrificed at various post irradiation intervals and liver was removed for quantitative estimation of Glutathione (GSH) and Lipid peroxidation (LPO). It was observed that GSH content decreased significantly on 5th day after exposure to 8Gy of gamma radiation in control group .Then it started to decrease on 7th day of the treatment. In the experimental group GSH content was higher as compared to their corresponding control . The animals which were treated with only AME showed greater protection. Irradiation resulted an elevation in lipid peroxidation level in liver. On the other hand, treatment of animals with Aegle marmelos before irradiation caused a significant decrease in LPO. These results indicate that Aegle marmelos protects from damage to the liver of Swiss albino mouse against of gamma radiations lethal dose