285-291Cigarette smoke (CS) is a rich source of radicals, predisposing the cell to oxidative stress resulting in inflammation. Chronic inflammation is a recognized risk factor for carcinogenesis. Cyclooxygenase-2 (COX-2) is a mediator of inflammatory pathway and may, therefore, contribute to carcinogenesis. There are several reports that suggest the association between CS and COX-2 associated risk to cancer. In the present study, we examined the role of celecoxib (a selective COX-2 inhibitor) in modulating the oxidative stress caused by CS inhalation in mice. CS exposure for a period of 10 weeks caused oxidative stress in the pulmonary and hepatic tissues, as evident from the increase in lipid peroxidation levels (LPO) and decreas...
Cyclooxygenease-2 (COX-2) expression is a critical factor in inflammation, and plays an important ro...
Cigarette smoking, cyclooxygenase-2 (COX-2) and macrophages are independently associated with colore...
BACKGROUND AND AIMS: Activated hepatic stellate cells (HSCs) but not quiescent HSCs express cyclo-ox...
Celecoxib, a nonsteroidal anti-inflammatory drug that selectively targets cyclooxygenase-2, is a pro...
Cyclooxygenase (COX) enzyme expression is elevated in human and rodent lung tumors, and non-steroida...
Nonsteroidal antiinflammatory drugs (NSAIDs) have been shown to reduce cell growth in several tumors...
Abstract Background The goal of this study was to determine the effects of a selective Cyclooxygenas...
An adverse role for obstructive sleep apnea (OSA) in cancer epidemiology and outcomes has recently e...
Cisplatin is used to treat lung cancer;however, it is also a known carcinogen. Cyclooxygenase-2 (COX...
Chronic inflammation plays a crucial role in the carcinogenesis process and in particular in smoking...
ObjectivesCyclooxygenase-2 plays a role in growth, apoptosis, angiogenesis, and metastasis in lung c...
The multiple cytoprotective mechanisms of heme oxygenase HO- 1 make it a promising therapeutic targe...
The interactions of cigarette smoking with COX-2 on colitis and colitis-associated adenoma formation...
Cigarette smoke has been shown to cause gastric cancer. Overexpression of cyclooxygenase-2 (COX-2) i...
Cancer is the main cause of death, followed by cardiovascular disease. Among thecategories of antica...
Cyclooxygenease-2 (COX-2) expression is a critical factor in inflammation, and plays an important ro...
Cigarette smoking, cyclooxygenase-2 (COX-2) and macrophages are independently associated with colore...
BACKGROUND AND AIMS: Activated hepatic stellate cells (HSCs) but not quiescent HSCs express cyclo-ox...
Celecoxib, a nonsteroidal anti-inflammatory drug that selectively targets cyclooxygenase-2, is a pro...
Cyclooxygenase (COX) enzyme expression is elevated in human and rodent lung tumors, and non-steroida...
Nonsteroidal antiinflammatory drugs (NSAIDs) have been shown to reduce cell growth in several tumors...
Abstract Background The goal of this study was to determine the effects of a selective Cyclooxygenas...
An adverse role for obstructive sleep apnea (OSA) in cancer epidemiology and outcomes has recently e...
Cisplatin is used to treat lung cancer;however, it is also a known carcinogen. Cyclooxygenase-2 (COX...
Chronic inflammation plays a crucial role in the carcinogenesis process and in particular in smoking...
ObjectivesCyclooxygenase-2 plays a role in growth, apoptosis, angiogenesis, and metastasis in lung c...
The multiple cytoprotective mechanisms of heme oxygenase HO- 1 make it a promising therapeutic targe...
The interactions of cigarette smoking with COX-2 on colitis and colitis-associated adenoma formation...
Cigarette smoke has been shown to cause gastric cancer. Overexpression of cyclooxygenase-2 (COX-2) i...
Cancer is the main cause of death, followed by cardiovascular disease. Among thecategories of antica...
Cyclooxygenease-2 (COX-2) expression is a critical factor in inflammation, and plays an important ro...
Cigarette smoking, cyclooxygenase-2 (COX-2) and macrophages are independently associated with colore...
BACKGROUND AND AIMS: Activated hepatic stellate cells (HSCs) but not quiescent HSCs express cyclo-ox...