Connect to Decode:A New Paradigm of Doing Science

19-22C2D demonstrates the power of people to connect through the Internet, particular young people, and accomplish complex research tasks. This exercise has provided a large number of clues towards obtaining a comprehensive view of the microbes as a whole, producing several testable hypotheses that can now be verified in the laboratory. Almost at the dawn of its creation in 2008, the Open Source Drug Discovery (OSDD) http://www.osdd.net programme, which is a CSIR-led Team India consortium with global partnership, had identified Mycobacterium tuberculosis (Mtb) as its first target. The reason is not far to seek. With a history going back to prehistoric times, TB has stalked the Earth for millennia, claiming Pharaohs of ancient Egypt as well as Poets of contemporary times. However, despite all our grand advances in science we have failed to wipe it off the face of the globe. Fortuitously for us, however, the IT-revolution in the early days of the twenty-first century has powered Genomics research such that looking at genomes has become easier. Rational drug discovery hinges on knowing the best target to attack, the best pathway to exploit and to do so while wasting a minimum of resources, including time. Knowing the genome is now the first step to knowing how to control a pathogen