Add to ORKG2710-2715L-Tryptophan methyl ester hydrochloride 2 undergoes Pictet-Spengler reaction with aromatic aldehydes in non-acidic aprotic media to furnish tetrahydro--carbolines. The reaction proceeds in good yield and excellent diastereoselectivity giving cis isomers 4a-c and 6a as the major product. Use of an optically active aldehyde 10 for this reaction yields enantiopure cis-1,3-disubstituted 1,2,3,4-tetrahydro--carboline 11
The Pictet–Spengler reaction (PSR) is the reaction of a β-arylethylamine with an aldehyde or ketone,...
A novel one-pot synthesis of tetrahydro-β-carboline systems via tandem hydroformylation–Pictet–Speng...
A novel one-pot synthesis of tetrahydro-β-carboline systems via tandem hydroformylation–Pictet–Speng...
The diastereoselective synthesis of optically active 1,3-disubstituted tetrahydro-beta-carbolines us...
N-beta-(3-Indolyl)ethyl amino acid esters and differently substituted aromatic aldehydes in the pres...
A catalytic asymmetric Pictet−Spengler reaction has been developed, wherein treating substituted try...
N-beta-(3-Indolyl)ethyl amino acid esters and differently substituted aromatic aldehydes in the pres...
The Pictet-Spengler cyclization of iminium salts generated in situ from N-(beta-3-indolyl)ethyl subs...
The Pictet-Spengler cyclization of iminium salts generated in situ from N-(beta-3-indolyl)ethyl subs...
Aromatic and aliphatic Schiff bases of tryptamine react with Fmoc- or ph-thaloyl-protected amino aci...
Aromatic and aliphatic Schiff bases of tryptamine react with Fmoc- or ph-thaloyl-protected amino aci...
Optically active tetrahydro-beta-carbolines were synthesized via an (R)-BINOL-phosphoric acid-cataly...
Asymmetric Pictet-Spengler reaction of a number of aldehydes with Abrine methyl ester (1) was perfor...
Enantioconvergent iso-Pictet-Spengler reactions of chiral racemic ß-formyl esters and a ß-keto ester...
The Pictet–Spengler reaction (PSR) is the reaction of a β-arylethylamine with an aldehyde or ketone,...
The Pictet–Spengler reaction (PSR) is the reaction of a β-arylethylamine with an aldehyde or ketone,...
A novel one-pot synthesis of tetrahydro-β-carboline systems via tandem hydroformylation–Pictet–Speng...
A novel one-pot synthesis of tetrahydro-β-carboline systems via tandem hydroformylation–Pictet–Speng...
The diastereoselective synthesis of optically active 1,3-disubstituted tetrahydro-beta-carbolines us...
N-beta-(3-Indolyl)ethyl amino acid esters and differently substituted aromatic aldehydes in the pres...
A catalytic asymmetric Pictet−Spengler reaction has been developed, wherein treating substituted try...
N-beta-(3-Indolyl)ethyl amino acid esters and differently substituted aromatic aldehydes in the pres...
The Pictet-Spengler cyclization of iminium salts generated in situ from N-(beta-3-indolyl)ethyl subs...
The Pictet-Spengler cyclization of iminium salts generated in situ from N-(beta-3-indolyl)ethyl subs...
Aromatic and aliphatic Schiff bases of tryptamine react with Fmoc- or ph-thaloyl-protected amino aci...
Aromatic and aliphatic Schiff bases of tryptamine react with Fmoc- or ph-thaloyl-protected amino aci...
Optically active tetrahydro-beta-carbolines were synthesized via an (R)-BINOL-phosphoric acid-cataly...
Asymmetric Pictet-Spengler reaction of a number of aldehydes with Abrine methyl ester (1) was perfor...
Enantioconvergent iso-Pictet-Spengler reactions of chiral racemic ß-formyl esters and a ß-keto ester...
The Pictet–Spengler reaction (PSR) is the reaction of a β-arylethylamine with an aldehyde or ketone,...
The Pictet–Spengler reaction (PSR) is the reaction of a β-arylethylamine with an aldehyde or ketone,...
A novel one-pot synthesis of tetrahydro-β-carboline systems via tandem hydroformylation–Pictet–Speng...
A novel one-pot synthesis of tetrahydro-β-carboline systems via tandem hydroformylation–Pictet–Speng...