185-193Isolated goat detrusor muscle exhibited spontaneous contractility with an irregular amplitude and frequency. The spontaneity of detrusor muscle exhibited a mean amplitude as 11.99 ± 0.83 mm and frequency as 1.37 ± 0.16/min. KATP-channel openers namely, cromakalim or pinacidil (10-7-10-4 M) added cumulatively, elicited a concentration-related inhibition of both amplitude and rate of spontaneous contractions. The mean IC50 values for both amplitude and frequency for cromakalim were 3.3 × 10-6 M and 2.9 × 10-6 M, respectively; and for pinacidil were 2.0 × 10-5 M and 1.5 × 10-5 M, respectively. Glibenclamide, a KATP-channel blocker inhibited the cromakalim-induced concentration-related relaxation of spontaneous contractions with a signif...
<p>(A) Isometric force recordings showing the relaxations evoked by electrical field stimulation (EF...
The definitive version may be found at www.wiley.comObjectiveTo examine the role of pH-sensitive K(+...
Increased phasic activity in the bladder smooth muscle of animal models and patients with detrusor o...
To investigate the influence of the mucosa on the inhibitory effects of the ATP-sensitive potassium ...
The potassium (K+) channel opening activity of ZM244085 (9-(3-cyanophenyl)-3,4,6,7,9,10-hexahydro-1,...
The activity of a recent KATP channel opener, the N-(4-Phenylsulfonylphenyl)-3,3,3-trifluoro-2-hydro...
The activity of a recent K(ATP) channel opener, the N-(4-Phenylsulfonylphenyl)-3,3,3-trifluoro-2-hyd...
Overactive bladder (OAB), often characterized by increased detrusor smooth muscle (DSM) contractilit...
Overactive bladder (OAB), often characterized by increased detrusor smooth muscle (DSM) contractilit...
We have investigated the effects of MCC-134 (1-[4-(1H-imidazol-1-yl)benzoyl]-N-methyl-cyclobutanecar...
ATP-sensitive K1 (KATP) channels play important roles in the regulation of excitability in urinary b...
BACKGROUND AND PURPOSE As adenosine 5'-triphosphate (ATP) is one of the inhibitory mediators of t...
We infused cromakalim, a K+ATP-sensitive channel opener (80microg(kg as a bolus, followed by 1 micro...
Prostacyclin is suggested to reduce microvascular permeability, but the cellular mechanisms mediatin...
PURPOSE: Adenosine triphosphate (ATP) (Sigma Chemical Co., St. Louis, Missouri) is known to contract...
<p>(A) Isometric force recordings showing the relaxations evoked by electrical field stimulation (EF...
The definitive version may be found at www.wiley.comObjectiveTo examine the role of pH-sensitive K(+...
Increased phasic activity in the bladder smooth muscle of animal models and patients with detrusor o...
To investigate the influence of the mucosa on the inhibitory effects of the ATP-sensitive potassium ...
The potassium (K+) channel opening activity of ZM244085 (9-(3-cyanophenyl)-3,4,6,7,9,10-hexahydro-1,...
The activity of a recent KATP channel opener, the N-(4-Phenylsulfonylphenyl)-3,3,3-trifluoro-2-hydro...
The activity of a recent K(ATP) channel opener, the N-(4-Phenylsulfonylphenyl)-3,3,3-trifluoro-2-hyd...
Overactive bladder (OAB), often characterized by increased detrusor smooth muscle (DSM) contractilit...
Overactive bladder (OAB), often characterized by increased detrusor smooth muscle (DSM) contractilit...
We have investigated the effects of MCC-134 (1-[4-(1H-imidazol-1-yl)benzoyl]-N-methyl-cyclobutanecar...
ATP-sensitive K1 (KATP) channels play important roles in the regulation of excitability in urinary b...
BACKGROUND AND PURPOSE As adenosine 5'-triphosphate (ATP) is one of the inhibitory mediators of t...
We infused cromakalim, a K+ATP-sensitive channel opener (80microg(kg as a bolus, followed by 1 micro...
Prostacyclin is suggested to reduce microvascular permeability, but the cellular mechanisms mediatin...
PURPOSE: Adenosine triphosphate (ATP) (Sigma Chemical Co., St. Louis, Missouri) is known to contract...
<p>(A) Isometric force recordings showing the relaxations evoked by electrical field stimulation (EF...
The definitive version may be found at www.wiley.comObjectiveTo examine the role of pH-sensitive K(+...
Increased phasic activity in the bladder smooth muscle of animal models and patients with detrusor o...