Regioselective reaction: Synthesis of novel Mannich bases derived from 3-(4,6-disubstituted-2-thiomethylpyrimidyl)-4-amino-5-mercapto-1,2-4-triazoles and their antimicrobial properties

1858-1864A new series of 3-(4,6-disubstituted-2-thiomethylpyrimidyl)-4-amino-5-mercapto-1,2-4-triazoles have been synthesized. These triazoles on reaction with aldehydes in the presence of acid catalyst forms Schiff’s bases. These Schiff’s bases can exist both in the thiol as well as in the thione tautomeric form. However when these compounds are subjected to Mannich reaction, N-Mannich bases 7a-f are obtained rather than the S-Mannich bases. The structures of the new compounds have been confirmed by spectral and analytical data. Few of these Mannich bases have been evaluated for their possible antifungal and antibacterial activity. Most of the tested compounds show significant antifungal and antibacterial activity