Rejection is the major barrier to successful transplantation and usually results from the integration of multiple mechanisms. Activation of elements of the innate immune system, triggered as a consequence of tissue injury sustained during cell isolation or organ retrieval as well as ischemia-reperfusion, will initiate and amplify the adaptive response. For cell mediated rejection, T cells require multiple signals for activation, the minimum being two signals; antigen recognition and costimulation. The majority of B cells require help from T cells to initiate alloantibody production. Antibodies reactive to donor HLA molecules, minor histocompatibility antigens, endothelial cells, red blood cells, or autoantigens can trigger or contribute to ...
David Chang, Jon Kobashigawa Cedars-Sinai Heart Institute, Los Angeles, CA, USA Abstract: Heart tra...
Organ transplantation remains the most important therapeutic option for end-stage organ failure, but...
Over the last decades, our understanding of adaptive immune responses to solid organ transplantation...
Rejection is the major barrier to successful transplantation and usually results from the integratio...
Rejection of transplanted organs depends on an orchestrated immune response to histocompatibility an...
International audienceOrgan transplantation appears today to be the best alternative to replace the ...
Experimental clinical evidence has highlighted the importance of early posttransplantation events in...
Transplantation is the most effective treatment for end-stage organ failure, but organ survival is l...
textabstractWhen a micro-organism penetrates the body, defensive mechanisms of the non-specific inna...
AbstractThe alloimmune response can be divided into specific junctures where critical decisions betw...
CONCLUSION Transplantation is the treatment of choice for end-stage kidney, heart, lung, and liver d...
Liver allograft rejection remains a significant cause of morbidity and graft failure in liver transp...
A number of life-threatening diseases, such as kidney failure, diabetes, and certain kinds of corona...
It has long been appreciated that MHC alloantigens can be recognized via two pathways; direct and in...
Over the last decades, our understanding of adaptive immune responses to solid organ transplantation...
David Chang, Jon Kobashigawa Cedars-Sinai Heart Institute, Los Angeles, CA, USA Abstract: Heart tra...
Organ transplantation remains the most important therapeutic option for end-stage organ failure, but...
Over the last decades, our understanding of adaptive immune responses to solid organ transplantation...
Rejection is the major barrier to successful transplantation and usually results from the integratio...
Rejection of transplanted organs depends on an orchestrated immune response to histocompatibility an...
International audienceOrgan transplantation appears today to be the best alternative to replace the ...
Experimental clinical evidence has highlighted the importance of early posttransplantation events in...
Transplantation is the most effective treatment for end-stage organ failure, but organ survival is l...
textabstractWhen a micro-organism penetrates the body, defensive mechanisms of the non-specific inna...
AbstractThe alloimmune response can be divided into specific junctures where critical decisions betw...
CONCLUSION Transplantation is the treatment of choice for end-stage kidney, heart, lung, and liver d...
Liver allograft rejection remains a significant cause of morbidity and graft failure in liver transp...
A number of life-threatening diseases, such as kidney failure, diabetes, and certain kinds of corona...
It has long been appreciated that MHC alloantigens can be recognized via two pathways; direct and in...
Over the last decades, our understanding of adaptive immune responses to solid organ transplantation...
David Chang, Jon Kobashigawa Cedars-Sinai Heart Institute, Los Angeles, CA, USA Abstract: Heart tra...
Organ transplantation remains the most important therapeutic option for end-stage organ failure, but...
Over the last decades, our understanding of adaptive immune responses to solid organ transplantation...