Bisphosphonate-related Osteonecrosis of the Human Jaw: a combined 3D assessment of Bone Descriptors by Histology and Synchrotron Radiation-based Microtomography.

Bisphosphonate-related osteonecrosis of the jaw (BRONJ), as other bone diseases, is supposed to be associated with an unbalanced bone remodeling process: thus, the full comprehension of the pathophysiology is fundamental to advance its treatment. Histological studies of morphometry and mineralization degree of jaw sites have shown many histopathological aspects [1]; however, there is also the need for quantitative three-dimensional (3D) imaging at the nanoscale. Recently, differences in lacunar morphology and peri-lacunar tissue properties at the submicrometer length scale were investigated by synchrotron radiation-based X-ray microtomography (SR-microCT) in human jaw bone samples obtained from both healthy subjects and patients suffering from BRONJ [2]...