Osteoinductive properties study of collagenated Dual-Blocks by synchrotron radiation phase-contrast microtomography

The restoration of large bony maxillofacial defects represents one of the tissue engineering main challenges. It has been recently explored using cells and tissues developed in vitro that should ideally be immunologically, functionally, structurally and mechanically identical to the native tissue. In the present study, the early stages of in vitro bone formation in a xenofree culture system of human Periodontal Ligament Stem Cells and collagenated porcine Dual-Blocks were investigated by Synchrotron Radiation X-ray phase contrast micro-computed tomography (SR micro-CT)