Post-load insulin resistance does not predict virological response to treatment of chronic hepatitis C patients without the metabolic syndrome.
- G. Fattovich
- M. Pasino
- I. Pierantonelli
- L. Covolo
- D. Ieluzzi
- N. Passigato
- A. Tonon
- M. G. Faraci
- M. Guido
- F. Negro
- SVEGLIATI BARONI, Gianluca
DOIAbstract
The role of insulin resistance in predicting virological response to therapy of chronic hepatitis C is debated. We assessed the association between basal (defined as homeostasis model assessment of insulin resistance (HOMA-IR)>2) and post-load insulin resistance (as oral glucose insulin sensitivity index<9.8 mg/kg/min) with the rapid and sustained virological responses in chronic hepatitis C.Observational prospective study of 124 treatment-naïve patients with chronic hepatitis C not fulfilling the metabolic syndrome criteria, adherent to a standard treatment with pegylated interferon alpha plus ribavirin.Insulin resistance was detected in 50\% (by HOMA-IR) and 29\% (by oral glucose insulin sensitivity index) of patients. Independent predict...
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