Patients with high risk myelodysplasia (HR-MDS) and acute myeloid leukaemia (AML) with chromosomal changes involving deletion of the long arm of chromosome 5 (del5q), especially with complex karyotype, rarely have a durable response to combination chemotherapy. In the subgroup with monosomal karyotype there are no long term survivors (Fang et al., 2011) [1]. Recent experience indicates that the incidence of del5q in AML is ~20-30%, with only 20-25% of patients achieving complete remission (CR) (Farag et al., 2006) [2]. Additionally, therapy has significant toxicity, with induction death rates ~20% even in younger patients (Juliusson et al., 2009) [3]. This lack of efficacy provides the clinical rationale for combination/sequential therapy w...
Lenalidomide could effectively induce red blood cell (RBC) transfusion independence (TI) in patients...
Background: Myelodysplastic syndromes with chromosome 5 long arm deletion (5q-MDS) may benefit from ...
Myelodysplastic syndrome (MDS) with deletion of the long arm of the chromosome 5 (5q - syndrome, del...
AbstractPatients with high risk myelodysplasia (HR-MDS) and acute myeloid leukaemia (AML) with chrom...
Patients with high risk myelodysplasia (HR-MDS) and acute myeloid leukaemia (AML) with chromosomal c...
Background Patients with chromosome 5 abnormalities and high-risk myelodysplastic syndromes or acute...
Background Patients with chromosome 5 abnormalities and high-risk myelodysplastic syndromes or acute...
Objective The most typical cytogenetic aberration in myelodysplastic syndromes is del(5q), which, wh...
Objective: The most typical cytogenetic aberration in myelodysplastic syndromes is del(5q), which, w...
High proportion of del(5q) myelodysplastic (MDS) patients achieves transfusion independence and comp...
CONTEXT:Refractory acute myeloid leukemia (AML) is a difficult disease to control with second or thi...
In this Phase 1b study, the safety and tolerability of maintenance therapy, comprising lenalidomide ...
Abstract Background While lenalidomide (LEN) shows high efficacy in myelodysplastic syndromes (MDS) ...
Abdallah Abou Zahr,1 Ehab Saad Aldin,2 Rami S Komrokji,3 Amer M Zeidan4 1Section of Hematology/Oncol...
Clonal heterogeneity has not been described in patients with myelodysplastic syndrome with isolated ...
Lenalidomide could effectively induce red blood cell (RBC) transfusion independence (TI) in patients...
Background: Myelodysplastic syndromes with chromosome 5 long arm deletion (5q-MDS) may benefit from ...
Myelodysplastic syndrome (MDS) with deletion of the long arm of the chromosome 5 (5q - syndrome, del...
AbstractPatients with high risk myelodysplasia (HR-MDS) and acute myeloid leukaemia (AML) with chrom...
Patients with high risk myelodysplasia (HR-MDS) and acute myeloid leukaemia (AML) with chromosomal c...
Background Patients with chromosome 5 abnormalities and high-risk myelodysplastic syndromes or acute...
Background Patients with chromosome 5 abnormalities and high-risk myelodysplastic syndromes or acute...
Objective The most typical cytogenetic aberration in myelodysplastic syndromes is del(5q), which, wh...
Objective: The most typical cytogenetic aberration in myelodysplastic syndromes is del(5q), which, w...
High proportion of del(5q) myelodysplastic (MDS) patients achieves transfusion independence and comp...
CONTEXT:Refractory acute myeloid leukemia (AML) is a difficult disease to control with second or thi...
In this Phase 1b study, the safety and tolerability of maintenance therapy, comprising lenalidomide ...
Abstract Background While lenalidomide (LEN) shows high efficacy in myelodysplastic syndromes (MDS) ...
Abdallah Abou Zahr,1 Ehab Saad Aldin,2 Rami S Komrokji,3 Amer M Zeidan4 1Section of Hematology/Oncol...
Clonal heterogeneity has not been described in patients with myelodysplastic syndrome with isolated ...
Lenalidomide could effectively induce red blood cell (RBC) transfusion independence (TI) in patients...
Background: Myelodysplastic syndromes with chromosome 5 long arm deletion (5q-MDS) may benefit from ...
Myelodysplastic syndrome (MDS) with deletion of the long arm of the chromosome 5 (5q - syndrome, del...