Treatment of Staphylococcus aureus Biofilm infection by the quorum sensing inhibitor RIP
- Balaban N
- Cirioni O
- GIACOMETTI, Andrea
- GHISELLI, ROBERTO
- Braunstein JB
- Silvestri C
- MOCCHEGIANI, FEDERICO
- SABA, Vittorio
- SCALISE, Giorgio
Publication date
January 2007
DOI Publisher
American Society for Microbiology Language
EnglishAbstract
Abstract The quorum-sensing inhibitor RIP inhibits staphylococcal TRAP/agr systems and both TRAP- and agr-negative strains are deficient in biofilm formation in vivo, indicating the importance of quorum sensing to biofilms in the host. RIP injected systemically into rats has been found to have strong activity in preventing methicillin-resistant Staphylococcus aureus graft infections, suggesting that RIP can be used as a therapeutic agent
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