Thymectomy in early childhood: significant alterations of the CD4⁺CD45RA⁺CD62L⁺ T cell compartment in later life

The study was aimed to assess indicators of immunosenescence, such as the total counts of peripheral blood CD4+CD45RA+CD62L+ (naive) T cells, the numbers of T cell receptor excision circles (TRECs), and Ki67-expression as marker of peripheral replication in thymectomized patients (TP) (n=101) compared to age-matched healthy donors (HD) (n=81). In TP, there was an inverse correlation between naive T cells and chronological age (p<0.001) or time post thymectomy (p<0.001). TP demonstrated lower TREC numbers in naive T cells compared to HD (p<0.001). TREC numbers negatively correlated with time post thymectomy (p<0.001). Percentages of Ki67-expresssing naive T cells were higher in TP compared to HD (p