Add to ORKGImmunization with irradiated sporozoites can protect against malaria infection and intensive efforts are aimed at reproducing this effect with subunit vaccines. A particular sequence of subunit immunization with pre-erythrocytic antigens of Plasmodium berghei, consisting of single dose priming with plasmid DNA followed by a single boost with a recombinant modified vaccinia virus Ankara (MVA) expressing the same antigen, induced unprecedented complete protection against P. berghei sporozoite challenge in two strains of mice. Protection was associated with very high levels of splenic peptide-specific interferon-gamma-secreting CD8+ T cells and was abrogated when the order of immunization was reversed. DNA priming followed by MVA boosting may ...
The search for an efficacious vaccine against malaria is ongoing, and it is now widely believed that...
The search for an efficacious vaccine against malaria is ongoing, and it is now widely believed that...
The persistence of immunity to malaria induced in mice by a heterologous DNA priming and poxvirus bo...
CD8+ T cells have been implicated as critical effector cells in protection against the pre-erythrocy...
CD8+ T cells have been implicated as critical effector cells in protection against the pre-erythro-c...
In influenza and malaria, CD8+ T cells play an important role in protective immunity in mice. An imm...
In animals, effective immune responses against malignancies and against several infectious pathogens...
The desirability of inducing cytotoxic T cell responses to defined epitopes in humans has led to the...
An effective vaccine against malaria is urgently required to relieve the immense human suffering and...
During the twentieth century, the primary approach to malaria prevention has been to interfere with ...
A highly effective vaccine against malaria is urgently needed, with leading vaccination strategies i...
A highly effective vaccine against malaria is urgently needed, with leading vaccination strategies i...
A generic approach to inducing high level CD8+ T cell responses would be of value for prophylactic a...
Although sterilizing immunity to malaria can be elicited by irradiated sporozoite vaccination, no cl...
<div><p>Although sterilizing immunity to malaria can be elicited by irradiated sporozoite vaccinatio...
The search for an efficacious vaccine against malaria is ongoing, and it is now widely believed that...
The search for an efficacious vaccine against malaria is ongoing, and it is now widely believed that...
The persistence of immunity to malaria induced in mice by a heterologous DNA priming and poxvirus bo...
CD8+ T cells have been implicated as critical effector cells in protection against the pre-erythrocy...
CD8+ T cells have been implicated as critical effector cells in protection against the pre-erythro-c...
In influenza and malaria, CD8+ T cells play an important role in protective immunity in mice. An imm...
In animals, effective immune responses against malignancies and against several infectious pathogens...
The desirability of inducing cytotoxic T cell responses to defined epitopes in humans has led to the...
An effective vaccine against malaria is urgently required to relieve the immense human suffering and...
During the twentieth century, the primary approach to malaria prevention has been to interfere with ...
A highly effective vaccine against malaria is urgently needed, with leading vaccination strategies i...
A highly effective vaccine against malaria is urgently needed, with leading vaccination strategies i...
A generic approach to inducing high level CD8+ T cell responses would be of value for prophylactic a...
Although sterilizing immunity to malaria can be elicited by irradiated sporozoite vaccination, no cl...
<div><p>Although sterilizing immunity to malaria can be elicited by irradiated sporozoite vaccinatio...
The search for an efficacious vaccine against malaria is ongoing, and it is now widely believed that...
The search for an efficacious vaccine against malaria is ongoing, and it is now widely believed that...
The persistence of immunity to malaria induced in mice by a heterologous DNA priming and poxvirus bo...