Determination of RUNX2 single nucleotide polymorphism RS6930053 in class i, ii and iii malocclusions

Runt-related transcription factor 2 (RUNX2) plays important roles in osteoblast differentiation, tooth development and chondrocyte maturationhence its involvement in craniofacial development is paramount. Mutation in RUNX2 is implicated with cleidocranial dysplasiaa bone development disorder, while single nucleotide polymorphism (SNP) in RUNX2 is associated with Class II/2 malocclusion. This study aimed to determine RUNX2 SNP of DNA marker (rs6930053) in malocclusion patients from local population. (Copied from article)