In vivo analgesic and antiinflammatory effects of Tectona grandis Linn. stem bark extracts

Tectona grandis Linn. is a widespread hard wood plant used for both therapeutic and commercial purposes. It is native to South and Southeast Asia. The present study was carried out to investigate analgesic and antiinflammatory activities of T. grandis (Family Verbenaceae) stem bark extracts. We also determined the preliminary phytochemical screening and acute toxicity of the stem bark extract. Stem bark was extracted with ethanol (TGEE) and water (TGAE). Analgesic and antiinflammatory activities of these extracts were assessed in Wistar rats with hot plate test and carrageenan induced paw oedema model. At the doses used (200, 300 and 500 mg/kg), TGEE and TGAE showed significant and dose-dependent analgesic and antiinflammatory effects. The phytochemical analysis revealed the presence of flavonoids, alkaloids tannins, anthraquinones, saponins, carbohydrates and proteins. None of the extracts had acute toxicity activity up to 2000 mg/kg dose level. The TGEE and TGAE exhibited significant analgesic and antiinflammatory activities of T. grandis stem bark due to the presence of various phytoconstituents such as flavonoids, alkaloids, tannins, anthraquinones and saponins