Moxifloxacin-warfarin interaction

Warfarin has its origin as a rat poison and has become one of the widely used anticoagulant drugs to prevent thrombosis and embolism. Many medications, foods and vegetables can interact with warfarin and affect its blood thinning effect in the body. The antibiotic, moxifloxacin official product monograph indicated no interaction with concomitant warfarin treatment as this fourth generation synthetic fluoroquinolone antibiotic does not share the same cytochrome P450 system metabolism pathway with warfarin. However, we report a case of increased anticoagulant activity in a patient treated with moxifloxacin and warfarin causing prolonged hospital stay