Comparison between the effect of soybean and goat\u27s milk on tumou-marker enzyme activities during hepatocarcinogenesis in rats

Milk is a physiological fluid which has high nutritional value and soybean has strong antioxidant characteristics which is believed to inhibit carcinogenesis. The objective of this study was to investigate the effects of administration of soybean and goatâs milk on hepatocarcinogenesis in rats (fed with diethylnitrosamineDEN and acetylaminofluoreneAAF) by determining the activities of plasma gammaglutamyl transpeptidase (GGT) and alkaline phosphatase (ALP). Thirty-six rats from the species Sprague-Dawley were divided into 6 groups: control, DEN/AAF, soybean, DEN/AAF with soybean treatment, goatâs milk and DEN/AAF with goatâs milk treatment. Soybean and goatâs milk administrations were given 5 ml/day. The rats were sacrificed after 8 weeks and the blood was collected. Treatment with DEN/AAF caused an increase in ALP and GGT levels and a decrease in weight significantly (p0.05). However, a decrease in weight was observed in the rats given soybean as well as goatâs milk. The results obtained suggested that soybean and goatâs milk may work as anti cancer agents in hepatocarcinogenesis although further studies are required to further elucidate this aspect