Add to ORKGNaturally occurring variation in gene copy number is increasingly recognized as a heritable source of susceptibility to genetically complex diseases. Here we report strong association between FCGR3B copy number and risk of systemic lupus erythematosus (P = 2.7 x 10(-8)), microscopic polyangiitis (P = 2.9 x 10(-4)) and Wegener's granulomatosis in two independent cohorts from the UK (P = 3 x 10(-3)) and France (P = 1.1 x 10(-4)). We did not observe this association in the organ-specific Graves' disease or Addison's disease. Our findings suggest that low FCGR3B copy number, and in particular complete FCGR3B deficiency, has a key role in the development of systemic autoimmunity
Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong genetic component and etio...
The response of a leukocyte to immune complexes (ICs) is modulated by receptors for the Fc region of...
Identification of the genes underlying complex phenotypes and the definition of the evolutionary for...
Naturally occurring variation in gene copy number is increasingly recognized as a heritable source o...
There is increasing evidence that gene copy number (CN) variation influences clinical phenotype. The...
The Fcgamma-receptor locus on chromosome 1q23 shows copy-number variation (CNV), and it has previous...
Copy number variation (CNV) is common in genomic regions encoding immune-related genes and can impac...
Anti-glomerular basement membrane antibody disease (anti-GBM disease) is a rare disorder characteris...
Aim: There is increasing evidence that gene copy-number variation influences phenotypic variation. T...
Objective There is increasing evidence that variation in gene copy number (CN) influences clinical p...
Copy number (CN) variation (CNV) has been shown to be common in regions of the genome coding for imm...
Low-affinity Fc receptors (FcR) act as key mediators of the pathogenic effects of autoantibodies. In...
Identification of the genes underlying complex phenotypes and the definition of the evolutionary for...
The response of a leukocyte to immune complexes (ICs) is modulated by receptors for the Fc region of...
Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong genetic component and etio...
The response of a leukocyte to immune complexes (ICs) is modulated by receptors for the Fc region of...
Identification of the genes underlying complex phenotypes and the definition of the evolutionary for...
Naturally occurring variation in gene copy number is increasingly recognized as a heritable source o...
There is increasing evidence that gene copy number (CN) variation influences clinical phenotype. The...
The Fcgamma-receptor locus on chromosome 1q23 shows copy-number variation (CNV), and it has previous...
Copy number variation (CNV) is common in genomic regions encoding immune-related genes and can impac...
Anti-glomerular basement membrane antibody disease (anti-GBM disease) is a rare disorder characteris...
Aim: There is increasing evidence that gene copy-number variation influences phenotypic variation. T...
Objective There is increasing evidence that variation in gene copy number (CN) influences clinical p...
Copy number (CN) variation (CNV) has been shown to be common in regions of the genome coding for imm...
Low-affinity Fc receptors (FcR) act as key mediators of the pathogenic effects of autoantibodies. In...
Identification of the genes underlying complex phenotypes and the definition of the evolutionary for...
The response of a leukocyte to immune complexes (ICs) is modulated by receptors for the Fc region of...
Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong genetic component and etio...
The response of a leukocyte to immune complexes (ICs) is modulated by receptors for the Fc region of...
Identification of the genes underlying complex phenotypes and the definition of the evolutionary for...