The fruit fly genome is characterized by an evolutionary expansion of proteases and immunity-related genes. In order to characterize the proteases that are active in a phagocytic Drosophila model cell line (S2 cells), we have applied a functional proteomics approach that allows simultaneous detection and identification of multiple protease species. DCG-04, a biotinylated, mechanism-based probe that covalently targets mammalian cysteine proteases of the papain family was found to detect Drosophila polypeptides in an activity-dependent manner. Chemical tagging combined with tandem mass spectrometry permitted retrieval and identification of these polypeptides. Among them was thiol-ester motif-containing protein (TEP) 4 which is involved in ins...
In this study, we analyzed the hemolymph proteome of Drosophila third instar larvae, which were indu...
The Drosophila dorsal Air Sac Primordium (ASP) is a tracheal tube that invasively grows toward and i...
Some allergens with relevant protease activity have the potential to directly interact with host str...
The fruit fly genome is characterized by an evolutionary expansion of proteases and immunity-related...
The fruit fly genome is characterized by an evolutionary expansion of proteases and immunity-related...
Insects respond to microbial infection by the rapid and transient expression of several genes encodi...
Innate immunity is based on the recognition of cell-sur-face molecules of infecting agents. Microbia...
Systematically annotating function of enzymes that belong to large protein families encoded in a sin...
Cysteine cathepsins are an important class of fifteen proteases with involvement in normal developme...
Here, we report the identification of proteins associated with the immune response of Drosophila by ...
Insect innate immunity is both a model for vertebrate immunity as well as a key system that impactsm...
Systematically annotating function of enzymes that belong to large protein families encoded in a sin...
Cysteine cathepsins are an important class of fifteen proteases with involvement in normal developme...
This study addresses the biological function of CG18594, a Drosophila melanogaster phosphatidylethan...
Grâce au séquençage du génome de la drosophile en mars 2000, les analyses post-génomiques sur cet in...
In this study, we analyzed the hemolymph proteome of Drosophila third instar larvae, which were indu...
The Drosophila dorsal Air Sac Primordium (ASP) is a tracheal tube that invasively grows toward and i...
Some allergens with relevant protease activity have the potential to directly interact with host str...
The fruit fly genome is characterized by an evolutionary expansion of proteases and immunity-related...
The fruit fly genome is characterized by an evolutionary expansion of proteases and immunity-related...
Insects respond to microbial infection by the rapid and transient expression of several genes encodi...
Innate immunity is based on the recognition of cell-sur-face molecules of infecting agents. Microbia...
Systematically annotating function of enzymes that belong to large protein families encoded in a sin...
Cysteine cathepsins are an important class of fifteen proteases with involvement in normal developme...
Here, we report the identification of proteins associated with the immune response of Drosophila by ...
Insect innate immunity is both a model for vertebrate immunity as well as a key system that impactsm...
Systematically annotating function of enzymes that belong to large protein families encoded in a sin...
Cysteine cathepsins are an important class of fifteen proteases with involvement in normal developme...
This study addresses the biological function of CG18594, a Drosophila melanogaster phosphatidylethan...
Grâce au séquençage du génome de la drosophile en mars 2000, les analyses post-génomiques sur cet in...
In this study, we analyzed the hemolymph proteome of Drosophila third instar larvae, which were indu...
The Drosophila dorsal Air Sac Primordium (ASP) is a tracheal tube that invasively grows toward and i...
Some allergens with relevant protease activity have the potential to directly interact with host str...