BACKGROUND: The emergence of drug resistant typhoid fever is a major public health problem, especially in Asia. An oral single dose typhoid vaccine would have major advantages. M01ZH09 is a live oral single dose candidate typhoid vaccine containing Salmonella enterica serovar Typhi (Ty2 aroC(-)ssaV(-)) ZH9 with two independently attenuating deletions. Studies in healthy adults demonstrated immunogenicity and an acceptable safety profile. OBJECTIVES: We conducted a randomised placebo controlled, single-blind trial to evaluate the safety and immunogenicity of M01ZH09 in healthy Vietnamese children aged 5 to 14 years. METHODS: Subjects were randomly assigned to receive either a nominal dose of 5x10(9) CFU of M01ZH09 or placebo and were followe...
Each year, 12.1 to 20.6 million typhoid fever infections occur globally, of which 1% result in death...
Typhoid fever illnesses are responsible for more than 100 000 deaths worldwide each year. In Banglad...
BackgroundTyphoid fever is a substantial public health problem in Africa, yet there are few clinical...
BACKGROUND: The emergence of drug resistant typhoid fever is a major public health problem, especial...
BACKGROUND: The emergence of drug resistant typhoid fever is a major public health problem, especial...
BACKGROUND:Typhoid fever remains a significant cause of morbidity and mortality in developing countr...
IntroductionThere is a high global incidence of typhoid fever, with an annual mortality rate of 200,...
BACKGROUND: Typhoid persists as a major cause of global morbidity. While several licensed vaccines t...
IntroductionThere is a high global incidence of typhoid fever, with an annual mortality rate of 200,...
BACKGROUND Salmonella Typhi is a major cause of fever in children in low- and middle-income countrie...
Background: Typhoid vaccination is a public health priority in developing countries where young chil...
Background: Typhoid fever causes more than 21 million cases of disease and 200,000 deaths yearly wor...
Background Enteric fever is estimated to affect 11andndash;20 million people worldwide each year. Mo...
Typhoid fever remains a serious problem in developing countries. Current vaccines are licensed for i...
Background: One of the goals of this study was to learn the coverage, safety and logistics of a mass...
Each year, 12.1 to 20.6 million typhoid fever infections occur globally, of which 1% result in death...
Typhoid fever illnesses are responsible for more than 100 000 deaths worldwide each year. In Banglad...
BackgroundTyphoid fever is a substantial public health problem in Africa, yet there are few clinical...
BACKGROUND: The emergence of drug resistant typhoid fever is a major public health problem, especial...
BACKGROUND: The emergence of drug resistant typhoid fever is a major public health problem, especial...
BACKGROUND:Typhoid fever remains a significant cause of morbidity and mortality in developing countr...
IntroductionThere is a high global incidence of typhoid fever, with an annual mortality rate of 200,...
BACKGROUND: Typhoid persists as a major cause of global morbidity. While several licensed vaccines t...
IntroductionThere is a high global incidence of typhoid fever, with an annual mortality rate of 200,...
BACKGROUND Salmonella Typhi is a major cause of fever in children in low- and middle-income countrie...
Background: Typhoid vaccination is a public health priority in developing countries where young chil...
Background: Typhoid fever causes more than 21 million cases of disease and 200,000 deaths yearly wor...
Background Enteric fever is estimated to affect 11andndash;20 million people worldwide each year. Mo...
Typhoid fever remains a serious problem in developing countries. Current vaccines are licensed for i...
Background: One of the goals of this study was to learn the coverage, safety and logistics of a mass...
Each year, 12.1 to 20.6 million typhoid fever infections occur globally, of which 1% result in death...
Typhoid fever illnesses are responsible for more than 100 000 deaths worldwide each year. In Banglad...
BackgroundTyphoid fever is a substantial public health problem in Africa, yet there are few clinical...