Highly potent N-substituted delta-lactams have been rationally designed and synthesized by a concise route with a one-pot tandem reaction as key step. These iminosugars show weak inhibition of wild-type beta-glucocerebrosidase but 3- to 6-fold increases in mutant enzyme activity (N370S)
Amino-<i>myo</i>-inositol derivatives have been found to be potent inhibitors of glucocerebrosidase ...
A highly divergent route to lipophilic iminosugars that utilizes the thiol–ene reaction was develope...
The potent and selective inhibitor of β-glucosidases, noeurostegine, was evaluated as an inhibitor o...
A series of N-substituted ε-hexonolactams have been designed and prepared by a concise route with a ...
A series of N-substituted e-hexonolactams have been designed and prepared by a concise route with a ...
We report on the synthesis and biological evaluation of a series of α-1-C-alkylated 1,4-dideoxy-1,4-...
A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the con...
A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the con...
A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the con...
Amino-myo-inositol derivatives have been found to be potent inhibitors of glucocerebrosidase (GCase)...
Chaperone Mediated Therapy represents an innovative and strategic approach to treat lysosomal storag...
International audienceA series of 18 mono‐ to 14‐valent iminosugars with different ligands, scaffold...
The potent and selective inhibitor of β-glucosidases, noeurostegine, was evaluated as an inhibitor o...
A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the co...
Gaucher disease is a lysosomal storage disorder in which the activity of the enzyme glucocerebrosida...
Amino-<i>myo</i>-inositol derivatives have been found to be potent inhibitors of glucocerebrosidase ...
A highly divergent route to lipophilic iminosugars that utilizes the thiol–ene reaction was develope...
The potent and selective inhibitor of β-glucosidases, noeurostegine, was evaluated as an inhibitor o...
A series of N-substituted ε-hexonolactams have been designed and prepared by a concise route with a ...
A series of N-substituted e-hexonolactams have been designed and prepared by a concise route with a ...
We report on the synthesis and biological evaluation of a series of α-1-C-alkylated 1,4-dideoxy-1,4-...
A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the con...
A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the con...
A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the con...
Amino-myo-inositol derivatives have been found to be potent inhibitors of glucocerebrosidase (GCase)...
Chaperone Mediated Therapy represents an innovative and strategic approach to treat lysosomal storag...
International audienceA series of 18 mono‐ to 14‐valent iminosugars with different ligands, scaffold...
The potent and selective inhibitor of β-glucosidases, noeurostegine, was evaluated as an inhibitor o...
A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the co...
Gaucher disease is a lysosomal storage disorder in which the activity of the enzyme glucocerebrosida...
Amino-<i>myo</i>-inositol derivatives have been found to be potent inhibitors of glucocerebrosidase ...
A highly divergent route to lipophilic iminosugars that utilizes the thiol–ene reaction was develope...
The potent and selective inhibitor of β-glucosidases, noeurostegine, was evaluated as an inhibitor o...
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