Retinal Nerve Fiber Layer and Macula Ganglion Cell Thickness in Eyes with Primary Angle Closure

Decreased thickness of retina nerve fiber layer (RNFL) and ganglion cells of inner plexifom layer (GLIPL) in patients with glaucoma suspect can represent early detection of retina nerve defect. This retrospective study aims to determine the thickness of GLCIPL of patients with primary angle closure suspect (PACS), primary angle closure (PAC), and primary angle closure glaucoma (PACG). All patients who came to Department of Ophthalmology Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital from July to September 2015 were examined for the thickness of RNFL and GLIPL with ocular coherence tomography. Mann Whitney test was performed to analyse the thickness of RNFL and GLCIPL among 3 groups. Seventy six eyes form 40 patients within 75% female were enrolled with the distribution of 23 eyes with PACS, 15 eyes with PAC and 38 eyes with PACG. The mean (standard deviation) thickness of superior RNFL in PACS, PAC and PACG were 120.1(22.2)μm, 119.41(21.05)μm and 88.44(20.02) μm. Significant difference was found between PAC and PACG (p<0.001). The mean (SD) thickness of GLCIPL in the superior sector of PACS, PAC, and PACG were 82.1(6.2)μm, 80.50(6.4)μm and 69.5(4.3)μm, which the GLCIPL thickness between PAC and PACG was significant different (p<0.001). Primary angle closure glaucoma eyes showed the RNFL and GLCIPL was the thinnest, mean while in PAC eyes tend to thinner than PACS. Closed observation should be carried out in PAC eyes, especially in risk factors patients