Potensi Virus A/Ck/West Java/PWT-Wij/2006 Sebagai Vaksin

Potential virus A/Ck/West Java/PWT-Wij/06 for Vaccin. Vaccination program for controlling avian influenza (AI) virus infection in poultry have been emerged during the past 5 years in Indonesia. However, due to the mutation character of this virus the available vaccines were no longer effective. Therefore a new local isolate of avian influenza virus A/Ck/West Java/PwtWij/2006 was studied. The virus, formulated as inactive vaccine, was injected in to 3 weeks old of layer chickens intramuscularly. At 3 weeks after vaccination, vaccinated chickens were challenged against seven local isolates of HPAI H5N1 intranasaly. Unvaccinated chickens were included in the challenge test as control. Results showed that the vaccine produced 100% protection against A/Ck/West Java/Pwt-Wij/2006 (homologous), A/Ck/West Java/1067/ 2003, A/Ck/West Java/Hj-18/2007, and A/Ck/Payakumbuh/BPPVRII/2007; produced 90% protection against A/Ck/BB149/5/2007, and 80% protection against A/Ck/West Java/Hamd/ 2006 isolates. The vaccine also stoppped viral shedding by day 5 to 7 after challange. This study indicate that the new local isolate of avian influenza A/Ck/West Java/Pwt-Wij/2006 has good potency as vaccine with broad spectrum against a range of AI viruses available in Indonesia