Add to ORKGHepatitis A virus (HAV) antagonizes the innate immune response by inhibition of retinoic acid-inducible gene I (RIG-I)- and melanoma differentiation-associated gene 5 (MDA-5)-mediated interferon-beta gene expression. We show that this is due to an interaction of HAV with the signaling pathway component MAVS (mitochondrial antiviral signaling protein), in which the viral nonstructural protein 2B seems to be involved. In consequence, interferon regulatory factor 3 (IRF-3) is not activated. This resulzs in efficient suppression of IFN-beta synthesis
The interferon regulatory factor 7 (IRF-7) plays an important role in the monocyte (MO)-to-macrophag...
SummaryHost innate recognition triggers key immune responses for viral elimination. The sensing mech...
In response to virus infection, RIG-I senses viral RNA and activates the adaptor protein MAVS, which...
Hepatitis A virus (HAV) antagonizes the innate immune response by inhibition of retinoic acid-induci...
Hepatitis A virus (HAV) antagonizes the innate immune response by inhibition of Newcastle disease vi...
Hepatitis A virus antagonizes the innate immune response by inhibition of IRF-3 activation which res...
The subject of this dissertation is the suppression of interferon-beta induction by hepatitis A viru...
Beta interferon (IFN-) is involved in a wide range of cellular functions, and its secretionmust be t...
SummaryViral infection triggers host innate immune responses through activation of the transcription...
Type I interferons (IFNs) play a critical role in the host defense against viruses. Lymphocytic chor...
<div><p>Mitochondrial antiviral signaling protein (MAVS) is an essential adaptor molecule that is re...
Mitochondrial antiviral signaling protein (MAVS) is an essential adaptor molecule that is responsibl...
Hepatitis B virus (HBV) encodes the regulatory HBx protein, which is required for virus replication,...
Sensing viruses by pattern recognition receptors (PRR) triggers the innate immune system of the host...
SummaryThe mitochondrial antiviral signaling protein (MAVS) mediates the activation of NFκB and IRFs...
The interferon regulatory factor 7 (IRF-7) plays an important role in the monocyte (MO)-to-macrophag...
SummaryHost innate recognition triggers key immune responses for viral elimination. The sensing mech...
In response to virus infection, RIG-I senses viral RNA and activates the adaptor protein MAVS, which...
Hepatitis A virus (HAV) antagonizes the innate immune response by inhibition of retinoic acid-induci...
Hepatitis A virus (HAV) antagonizes the innate immune response by inhibition of Newcastle disease vi...
Hepatitis A virus antagonizes the innate immune response by inhibition of IRF-3 activation which res...
The subject of this dissertation is the suppression of interferon-beta induction by hepatitis A viru...
Beta interferon (IFN-) is involved in a wide range of cellular functions, and its secretionmust be t...
SummaryViral infection triggers host innate immune responses through activation of the transcription...
Type I interferons (IFNs) play a critical role in the host defense against viruses. Lymphocytic chor...
<div><p>Mitochondrial antiviral signaling protein (MAVS) is an essential adaptor molecule that is re...
Mitochondrial antiviral signaling protein (MAVS) is an essential adaptor molecule that is responsibl...
Hepatitis B virus (HBV) encodes the regulatory HBx protein, which is required for virus replication,...
Sensing viruses by pattern recognition receptors (PRR) triggers the innate immune system of the host...
SummaryThe mitochondrial antiviral signaling protein (MAVS) mediates the activation of NFκB and IRFs...
The interferon regulatory factor 7 (IRF-7) plays an important role in the monocyte (MO)-to-macrophag...
SummaryHost innate recognition triggers key immune responses for viral elimination. The sensing mech...
In response to virus infection, RIG-I senses viral RNA and activates the adaptor protein MAVS, which...