The Development and Use of New Methods and Strategies for the Monitoring of Nephrotoxicity and the Study of Renal Physiology: Proteomics- and Metabonomics-based Studies

A Key for avoiding the negative effects of immunosuppressant caused nephropathy after transplantation is early detection. This study shows a set of biomarkers, which could serve for the early detection of nephrotoxicity. Systematic development of a new model enables for the evaluation of drug induced nephrotoxicity and could be used for the development of new drugs in an early phase. We found indicators for the drug induced formation of reactive oxygen species, which could be causing the toxicity. The NMR-based model correlated with the 8-isoprostaglandin-F2aplha levels and the glomerular filtration rates showing the trend in toxicity:control<sirolimus<=tacrolimus<Sirl. Tac.<cyclosporine