The Effect of Cyperus Rotundus on Memory and the Number of Hippocampus Cells on Alcohol Administration

Background: Cyperus rotundus is a type of weed plant difficult to eradicate that has been popular as a traditional medicine in the traditional Asian medicine.The Objective: This study was conducted to see if Cyperus rotundus could prevent a decrease in the number of pyramidal hippocampal cells in mice due to ethanol administration.Method: Twenty-five male Spinoque-Dowley rats aged 30 days were divided into five groups were given mineral water, 25% alcohol, the ethanol extract of C.rotundus tuber with doses of 0.325, 0.75 and 2.5gr. Morris water maze testing performed on the first, second, third, tenth and seventh day of treatments. The rats are euthanasia with transcardial perfusion to take the hippocampus. Calculation of hippocampal cells is done by stereology.Result: From the Morris water maze test of hippocampal cell counting there were significant differences between groups. The highest number of hippocampus cells in the sequence are: Group 1, Group 4 and the smallest is Group 2. Similarly, Morris water maze test results of the fastest time in series are Groups 1, 4, 3, 5 and the longest 2. This condition suggests that ethanol decreases the number of hippocampal cells and decreases memory function. Also, C. rotundus has been shown to prevent a reduction in the number of hippocampal cells and avoid the decline in memory function.Conclusion: Ethanol causes a decrease in the number of hippocampal cells and decreased memory function, and C. rotundus can prevent a reduction in the number of hippocampal cells and decreased memory function