Coronal mass ejections (CMEs), in particular Earth-directed ones, are regarded as the main drivers of geomagnetic activity. In this study, we present a statistical analysis of a set of 53 fast (V ≥ 1000 km·s−1) Earth-directed halo CMEs observed by the SOHO/LASCO instrument during the period Jan. 2009–Sep. 2015, and we then use this CME sample to test the forecasting capabilities of a new Sun-to-Earth prediction scheme for the geoeffectiveness of Earth-directed halo CMEs. First, we investigate the CME association with other solar activity features such as solar flares, active regions, and others, by means of multi-instrument observations of the solar magnetic and plasma properties, with the final aim of identifying recurrent peculiar featur...