In this study we describe a previously unreported function for NFκB2, an NFκB family transcription factor, in antiviral immunity. NFκB2 is induced in response to poly(I:C), a mimic of viral dsRNA. Poly(I:C), acting via TLR3, induces p52-dependent transactivation of a reporter gene in a manner that requires the kinase activity of IκB kinase ϵ (IKKϵ) and the transactivating potential of RelA/p65. We identify a novel NFκB2 binding site in the promoter of the transcription factor Sp1 that is required for Sp1 gene transcription activated by poly(I:C). We show that Sp1 is required for IL-15 induction by both poly(I:C) and respiratory syncytial virus, a response that also requires NFκB2 and IKKϵ. Our study identifies NFκB2 as a target for IKKϵ in ...
Infection by herpes simplex virus type 1 (HSV-1) induces a persistent nuclear translocation of NFκB....
Nuclear factor-κB (NF-κB) is an important transcription factor that induces the expression of antivi...
AbstractNF-κB, a heterodimeric transcription factor composed of p50 and p65 subunits, can be activat...
In this study we describe a previously unreported function for NFκB2, an NFκB family transcription ...
In this study we describe a previously unreported function for NFκB2, an NFκB family transcription f...
SUMMARY Nuclear factor kappa B (NF-κB) transcription factors control many aspects of cell fate throu...
SummaryProduction of type I interferons (IFN-I) is a crucial innate immune mechanism against viral i...
AbstractAlthough Saimiri Transforming Protein (STP)-A11, an oncoprotein of Herpesvirus saimiri, has ...
The success of innate host defence to viral infection depends on the ability of innate immunecells t...
AbstractThe latent form of the dimeric transcription factor NF-κB is sequestered in the cytoplasm by...
SummaryNuclear factor kappa B (NF-κB) and type 1 interferon (T1-IFN) signaling are innate immune mec...
SummaryTranscription factors interferon regulatory factor 3 (IRF3) and nuclear factor κB (NFκB) are ...
Transcription factors interferon regulatory factor 3 (IRF3) and nuclear factor κB (NFκB) are activat...
Vaccinia virus (VV )has many mechanisms to suppress and modulate the host immune response. The VV pr...
AbstractNF-κB is a collective name given to a family of ubiquitous transcription factors (TFs) activ...
Infection by herpes simplex virus type 1 (HSV-1) induces a persistent nuclear translocation of NFκB....
Nuclear factor-κB (NF-κB) is an important transcription factor that induces the expression of antivi...
AbstractNF-κB, a heterodimeric transcription factor composed of p50 and p65 subunits, can be activat...
In this study we describe a previously unreported function for NFκB2, an NFκB family transcription ...
In this study we describe a previously unreported function for NFκB2, an NFκB family transcription f...
SUMMARY Nuclear factor kappa B (NF-κB) transcription factors control many aspects of cell fate throu...
SummaryProduction of type I interferons (IFN-I) is a crucial innate immune mechanism against viral i...
AbstractAlthough Saimiri Transforming Protein (STP)-A11, an oncoprotein of Herpesvirus saimiri, has ...
The success of innate host defence to viral infection depends on the ability of innate immunecells t...
AbstractThe latent form of the dimeric transcription factor NF-κB is sequestered in the cytoplasm by...
SummaryNuclear factor kappa B (NF-κB) and type 1 interferon (T1-IFN) signaling are innate immune mec...
SummaryTranscription factors interferon regulatory factor 3 (IRF3) and nuclear factor κB (NFκB) are ...
Transcription factors interferon regulatory factor 3 (IRF3) and nuclear factor κB (NFκB) are activat...
Vaccinia virus (VV )has many mechanisms to suppress and modulate the host immune response. The VV pr...
AbstractNF-κB is a collective name given to a family of ubiquitous transcription factors (TFs) activ...
Infection by herpes simplex virus type 1 (HSV-1) induces a persistent nuclear translocation of NFκB....
Nuclear factor-κB (NF-κB) is an important transcription factor that induces the expression of antivi...
AbstractNF-κB, a heterodimeric transcription factor composed of p50 and p65 subunits, can be activat...