Purple acid phosphatases from bacteria: similarities to mammalian and plant enzymes

Schenk, Gerhard
Korsinczky, Michael L.J.
Hume, David A.
Hamilton, Susan E.
de Jersey, John

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Publication date

January 2000

Publisher

Elsevier BV

Language

English

Abstract

Mammalian and plant purple acid phosphatases have similar active site structures despite low sequence identity (<20%). Although no bacterial enzyme has been purified, a sequence database search revealed that genes that could encode potential purple acid phosphatases may be restricted to a small number of organisms (i.e. myco- and cyanobacteria). Analysis of their deduced amino acid sequences and predicted secondary structures indicates that the cyanobacterial enzyme is similar to both the mammalian and the recently discovered low-molecular-weight plant purple acid phosphatases, while the mycobacterial enzyme is homologous to the fungal and high-molecular-weight plant purple acid phosphatases. Homology models indicate that both bacteri...

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Purple acid phosphatases from bacteria: similarities to mammalian and plant enzymes

Abstract

Extracted data

Purple acid phosphatases from bacteria: similarities to mammalian and plant enzymes

Abstract

Extracted data

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