Background: Multiple sclerosis (MS) is a complex trait in which genes in the MHC class II region exert the single strongest effect on genetic susceptibility. The principal MHC class II haplotype that increases MS risk in individuals of Northern European descent are those that bear HLA-DRB1*15. However, several other HLA-DRB1 alleles have been positively and negatively associated with MS and each of the main allelotypes is composed of many sub-allelotypes with slightly different sequence composition. Given the role of this locus in antigen presentation it has been suggested that variations in the peptide binding site of the allele may underlie allelic variation in disease risk. Methods: In an investigation of 7,333 individuals from 1,352 MS...
Multiple sclerosis is a common disease of the central nervous system in which the interplay between ...
The major histocompatibility complex (MHC) region is strongly associated with multiple sclerosis (MS...
Multiple sclerosis is a common disease of the central nervous system in which the interplay between ...
The major histocompatibility complex (MHC) region is strongly associated with multiple sclerosis (MS...
The major histocompatibility complex (MHC) region is strongly associated with multiple sclerosis (MS...
The major histocompatibility complex (MHC) region is strongly associated with multiple sclerosis (MS...
Multiple sclerosis is a common disease of the central nervous system in which the interplay between ...
The major histocompatibility complex (MHC) region is strongly associated with multiple sclerosis (MS...
Multiple sclerosis is a common disease of the central nervous system in which the interplay between ...
The major histocompatibility complex (MHC) region is strongly associated with multiple sclerosis (MS...
The major histocompatibility complex (MHC) region is strongly associated with multiple sclerosis (MS...
The major histocompatibility complex (MHC) region is strongly associated with multiple sclerosis (MS...
Multiple sclerosis is a common disease of the central nervous system in which the interplay between ...
The major histocompatibility complex (MHC) region is strongly associated with multiple sclerosis (MS...
Multiple sclerosis is a common disease of the central nervous system in which the interplay between ...