The neuropathological features of schizophrenia are suggestive of a developmentally induced impairment of synaptic connectivity. Semaphorin 3A (sema3A) might contribute to this process because it is a secreted chemorepellant which regulates axonal guidance. We have investigated sema3A in the cerebellum (an area in which expression persists in adulthood), and measured its abundance in 16 patients with schizophrenia and 16 controls. In adults, sema3A was predominantly localized to the inner part of the molecular layer neuropil, whereas infants and rats showed greater labelling of Purkinje cell bodies. Sema3A was increased in schizophrenia, as shown by enzyme-linked immunosorbent assay (+28%; P<0.05) and immunohistochemistry (+45%; P<0.0...
Semaphorins are a large family of cell-surface and secreted proteins that have been shown to functio...
Semaphorins (Sema) are an abundant and widely expressed family of membrane-associated and secreted p...
peer reviewedThe secreted semaphorin 3A (Sema3A) is a member of a large family of proteins that act ...
Semaphorins (Sema) belong to a large family of repellent guidance cues instrumental in guiding axons...
Our ability to perceive, to act and to remember is a reflection of the elaborate synaptic connection...
During postnatal development, closure of critical periods coincides with the appearance of extracell...
Psychiatric disorders such as schizophrenia and autism are characterised by cellular disorganisation...
Psychiatric disorders such as schizophrenia and autism are characterised by cellular disorganisation...
Semaphorin3A (Sema3A) is known to cause neuronal apoptosis and serves as a chemorepellent factor for...
Semaphorins (sema) constitute a family of molecules sharing a common extracellular domain (semaphori...
SummarySemaphorin 3A (Sema3A) is a secreted factor known to guide axon/dendrite growth and neuronal ...
Alterations in neuronal connectivity of the mature central nervous system (CNS) appear to depend on ...
Secreted semaphorins are essential for neural development and continue to be expressed in subpopulat...
In the developing nervous system, extending axons are directed towards their appropriate targets by ...
A cortico-subcortico-cerebellar neural circuit has been postulated to be important in the pathophysi...
Semaphorins are a large family of cell-surface and secreted proteins that have been shown to functio...
Semaphorins (Sema) are an abundant and widely expressed family of membrane-associated and secreted p...
peer reviewedThe secreted semaphorin 3A (Sema3A) is a member of a large family of proteins that act ...
Semaphorins (Sema) belong to a large family of repellent guidance cues instrumental in guiding axons...
Our ability to perceive, to act and to remember is a reflection of the elaborate synaptic connection...
During postnatal development, closure of critical periods coincides with the appearance of extracell...
Psychiatric disorders such as schizophrenia and autism are characterised by cellular disorganisation...
Psychiatric disorders such as schizophrenia and autism are characterised by cellular disorganisation...
Semaphorin3A (Sema3A) is known to cause neuronal apoptosis and serves as a chemorepellent factor for...
Semaphorins (sema) constitute a family of molecules sharing a common extracellular domain (semaphori...
SummarySemaphorin 3A (Sema3A) is a secreted factor known to guide axon/dendrite growth and neuronal ...
Alterations in neuronal connectivity of the mature central nervous system (CNS) appear to depend on ...
Secreted semaphorins are essential for neural development and continue to be expressed in subpopulat...
In the developing nervous system, extending axons are directed towards their appropriate targets by ...
A cortico-subcortico-cerebellar neural circuit has been postulated to be important in the pathophysi...
Semaphorins are a large family of cell-surface and secreted proteins that have been shown to functio...
Semaphorins (Sema) are an abundant and widely expressed family of membrane-associated and secreted p...
peer reviewedThe secreted semaphorin 3A (Sema3A) is a member of a large family of proteins that act ...