The charge dynamical response function of the $t\mbox{-}t'\mbox{-}U$ Hubbard model is investigated on the square lattice in the thermodynamical limit. The correlation function is calculated from Gaussian fluctuations around the paramagnetic saddle-point within the Kotliar and Ruckenstein slave-boson representation. The next-nearest-neighbor hopping only slightly affects the renormalization of the quasiparticle mass. In contrast a negative $t'/t$ notably decreases (increases) their velocity, and hence the zero-sound velocity, at positive (negative) doping. For low (high) density $n \lesssim 0.5\ (n \gtrsim 1.5)$ we find that it enhances (reduces) the damping of the zero-sound mode. Furthermore it softens (hardens) the upper-Hubbard-band c...