Inflammation markers in the saliva of infants born from Zika-infected mothers: exploring potential mechanisms of microcephaly during fetal development
- Oliveira, Diogo N. de
- Lima, Estela O.
- Melo, Carlos F. O. R.
- Delafiori, Jeany
- Guerreiro, Tatiane M.
- Rodrigues, Rafael G. M.
- Morishita, Karen N.
- Silveira, Cynthia
- Muraro, Stefanie Primon
- Souza, Gabriela Fabiano de
- Vieira, Aline
- Silva, Antonio
- Batista, Rosangela F.
- Doriqui, Maria J. R.
- Sousa, Patricia S.
- Milanez, Guilherme P.
- Proenca-Modena, Jose L.
- Cavalcanti, Denise P.
- Catharino, Rodrigo R.
DOIAbstract
Zika virus (ZIKV) has emerged as one of the most medically relevant viral infections of the past decades; the devastating effects of this virus over the developing brain are a major matter of concern during pregnancy. Although the connection with congenital malformations are well documented, the mechanisms by which ZIKV reach the central nervous system (CNS) and the causes of impaired cortical growth in affected fetuses need to be better addressed. We performed a non-invasive, meta bolomicsbased screening of saliva from infants with congenital Zika syndrome (CZS), born from mothers that were infected with ZIKV during pregnancy. We were able to identify three biomarkers that suggest that this population suffered from an important inflammator...
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