Zea Mays L to The Decreasing Blood Glucose Levels in Animal Trial (Rat) with Diabetes Mellitus: Systematic Review

Background: Diabetes millitus (DM) is one of chronic disease that require long treatments, highly cost treatment, in addition DM prevalence rate is increased continuously. Pharmacological therapy given to DM patients has not been able to guarantee cure to DM patients such as Zea Mays L is know as one of traditional herbal medicine in China which has many traits such as hypoglycemic, anti tumor, anti oxidant, etc. Method: This systematic review begins with the selection of topic, then determines keywords to search the journals from various databases such as Google Scholar, ProQuest, Pub Med, Science Direct, Journal Of Nursing Science, and National Journal. Limited from 2009 to 2017, the English keywords use are “Zea mays L”, “corn silk”, “corn silk for diabetic”, “diabetic and herbal”. Result: From 16 journal conducted review the number of samples vary between 20 to 80 animals trials that have been treated with various corn silk extract and can be used as herbal therapy alternative to decrease blood glucose levels in animal trial (rat) with DM. Conclusion: Zea mays L is very significant to decrease blood glucose levels in animal trial (rat) with D